Xanthine Oxidoreductase Is an Endogenous Regulator of Cyclooxygenase-2

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Xanthine oxidoreductase is an endogenous regulator of cyclooxygenase-2.

Xanthine oxidoreductase (XOR) is the enzyme responsible for the final step in purine degradation resulting in the generation of uric acid. Here we have generated mice deficient in XOR. As expected, these animals lack tissue XOR activity and have low to undetectable serum levels of uric acid. Although normal at birth, XOR-/- mice fail to thrive after 10 to 14 days, and most die within the first ...

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The thermodynamics of xanthine oxidoreductase catalysis.

Xanthine oxidoreductase is a complex enzyme found in a wide range of organisms. Recent interest in this enzyme stems from its ability to produce reactive oxygen species under a range of conditions. It is found as a homodimer, each unit containing a molybdopterin cofactor, two iron sulfur centers, and FAD. The enzyme can exist in two forms that differ primarily in their oxidizing substrate speci...

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ژورنال

عنوان ژورنال: Circulation Research

سال: 2004

ISSN: 0009-7330,1524-4571

DOI: 10.1161/01.res.0000149571.96304.36