Xanthine Oxidoreductase Is an Endogenous Regulator of Cyclooxygenase-2
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چکیده
منابع مشابه
Xanthine oxidoreductase is an endogenous regulator of cyclooxygenase-2.
Xanthine oxidoreductase (XOR) is the enzyme responsible for the final step in purine degradation resulting in the generation of uric acid. Here we have generated mice deficient in XOR. As expected, these animals lack tissue XOR activity and have low to undetectable serum levels of uric acid. Although normal at birth, XOR-/- mice fail to thrive after 10 to 14 days, and most die within the first ...
متن کاملRegulation of xanthine oxidoreductase by intracellular iron.
Xanthine oxidoreductase (XOR) may produce reactive oxygen species and play a role in ischemia-reperfusion injury. Because tissue iron levels increase after ischemia, and because XOR contains functionally critical iron-sulfur clusters, we studied the effects of intracellular iron on XOR expression. Ferric ammonium citrate and FeSO(4) elevated intracellular iron levels and increased XOR activity ...
متن کاملExpression and Regulation of Human Xanthine Oxidoreductase
Yliopistopaino The truth is rarely pure and never simple.
متن کاملThe thermodynamics of xanthine oxidoreductase catalysis.
Xanthine oxidoreductase is a complex enzyme found in a wide range of organisms. Recent interest in this enzyme stems from its ability to produce reactive oxygen species under a range of conditions. It is found as a homodimer, each unit containing a molybdopterin cofactor, two iron sulfur centers, and FAD. The enzyme can exist in two forms that differ primarily in their oxidizing substrate speci...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2004
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000149571.96304.36